Multiscale, Multimodal, And Multidimensional Microscopy Of Cardiac Development

Michael Liebling, Sandeep Bhat, Jungho Ohn

Signal Processing Systems (SIPS), 2010 IEEE Workshop on.

Download PDF


In vivo fluorescence imaging of the embryonic zebrafish heart as it develops and gains function has recently become possible thanks to several breakthroughs in fast microscopy. However, because of the motion of the fast beating heart, volumetric, long term, continuous, and simultaneous characterization of subtle changes in heart morphology at the organ, tissue and cellular level, changes in heart function, or changes in local gene expression all remain major challenges. We have developed tools that aim at addressing the problem of capturing and integrating multi-modal data at different temporal and spatial scales to build a multi-dimensional model of the beating and developing heart. This paper gives an overview of techniques we developed and integrated to follow heart development, spatiotemporally confined hemodynamics, and gene expression. These tools permit quantitative characterization and will allow studying the interactions between genetic and epigenetic factors that affect cardiac development.


author={Liebling, M. and Bhat, S. and Jungho Ohn},
booktitle={Signal Processing Systems (SIPS), 2010 IEEE Workshop on}, title={Multiscale, multimodal, and multidimensional microscopy of cardiac development},
pages={227 -230},

Copyright © 2010 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from IEEE. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.

Warning: because your browser doesn't conform to current web standards, you are viewing a simplified version of this website! Note however, that apart from the layout, its content is unaltered.